Collagen is a biopolymer, the main component of animal connective tissue, and the most abundant and widely distributed functional protein in mammals, accounting for 2530 of the total protein, and even as high as 80 in some organisms. Animal tissues derived from livestock and poultry are the main way for people to obtain natural collagen and collagen peptides. However, the use of collagen and its products from terrestrial mammals is limited by related animals and some religious beliefs. The European Food Safety Authority (EFSA) has confirmed that even collagen derived from animal bones is free of BSE and other related possibilities. Due to the differences in amino acid composition and crosslinking degree, etc, make the aquatic animals, especially the processing waste of skin, bones and scales is contained in the rich collagen has many advantages of cattle collagen did not derived from Marine animal collagen in some other aspects are better than those of collagen of land animals, such as those with low antigenicity, hypoallergenic properties, etc. Therefore, aquatic collagen may gradually replace terrestrial animal collagen. Due to its good biocompatibility, biodegradability and bioactivity, collagen has been widely used in food, medicine, tissue engineering, cosmetics and other fields.